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SH2 domain structures
Gene Structures pdb_files
ABL1 ABL1 1OPJ, 1OPK, 1OPL
ABL1 SH2 1AB2
ABL1 SH3 + SH2 2ABL
APS SH2 Dimer 1RPY
APS SH2 + INSR 1RQQ
BLK SH2 1BLJ, 1BLK
BRK SH2 1RJA
CBL CBL + UBCH 1FBV
CBL TKB(SH2) + peptide 1YVH
CBL TKB(SH2) 1B47, 2CBL
CHN1 CHN1 1XA6
CRK SH2 + ABL SH3 + peptide 1JU5
CSK SH2 1JWO
CSK CSK 1K9A
FES SH2 1WQU
FYN SH2 + peptide 1AOT, 1AOU
FYN SH2 + SH3 1G83
FYN FYN + SAP + SLAM peptide 1M27
GADS SH2 + peptide 1R1P, 1R1Q, 1R1S
GRB10 SH2 1NRV
GRB14 SH2 2AUG
GRB2 SH2 + inhibitor 1CJ1, 1X0N, 2AOA, 2AOB
GRB2 SH2 1GHU, 1FHS, 1JYU
GRB2 SH2 + peptide 1BM2, 1BMB, 1FYR, 1JYQ, 1JYR, 1TZE, 1QG1, 1ZFP
GRB2 GRB2 1GRI
GRB7 SH2 + peptide 1MW4
HCK SH2 3HCK
HCK HCK 1AD5, 2HCK
HCK HCK + inhibitor 1QCF
ITK SH2 1LUI, 1LUK, 1LUM, 1LUN
ITK SH2 + peptide 2EU0, 2ETZ
LCK SH2 + inhibitor 1BHF, 1IJR
LCK SH2 1BHH
LCK SH2 + peptide 1LCJ, 1LKK, 1LKL
LCK SH3 + SH2 + peptide 1LCK, 1X27
LCK LCK 1CWD, 1CWE
NCK1 SH2 + peptide 2CI9
NCK1 SH2 2CI8
NCK2 SH2 + peptide 1Z3K, 2CIA
PIK3R1 N_SH2 2PNA, 2PNB, 1OO3, 1FU6
PIK3R1 N_SH2 + peptide 1FU5, 1OO4
PIK3R1 C_SH2 1BFI, 1BFJ
PIK3R1 C_SH2 + peptide 1H9O, 1PIC, 1QAD
PLCG1 C_SH2 + peptide 2FCI, 2PLE, 2PLD
PTPN11 PTPN11 2SHP
PTPN11 N_SH2 1AYA, 1AYB, 1AYC, 1AYD
PTPN6 PTPN6 2B3O
PTPN6 C_SH2 1X6C
SH2D1A SAP 1D1Z
SH2D1A SAP + peptide 1D4T, 1D4W, 1KA6, 1KA7
SH2D1A SAP + FYN + SLAM peptide 1M27
SH2D1B SH2 + peptide 1I3Z
SH3BP2 SH2 2CR4
SHC1 SH2 1MIL
SHC1 SH2 + peptide 1QG1, 1TCE
SOCS2 SH2 + peptide 2C9W
SOCS3 SH2 + peptide 2BBU
SRC SH2 1BKL, 1BKM
SRC SH2 + inhibitor 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4G, 1O4H, 1O4I, 1O4J, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 104R, 1FBZ, 1IS0, 1SKJ
SRC SH2 + peptide 1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1HCS, 1HCT, 1KC2, 1NZL, 1NZV, 1P13, 1SHA, 1SHB, 1SHD, 1SPR
SRC SRC 1FMK, 1KSW, 1SPS, 2SRC, 2PTK
SRC SRC SH2 T215W (Grb2) + peptide 1F1W, 1F2F
STAT1 STAT1 + DNA 1BF5
STAT1 STAT1 1UUR, 1UUS
STAT1 STAT1 + peptide 1YVL
STAT3 STAT3 +DNA 1BG1
STAT5a STAT5a 1Y1U
SYK N&C_SH2 + peptide 1A81
SYK C_SH2 + peptide 1CSY, 1CSZ
VAV1 SH2 2CRH
ZAP70 N&C_SH2 1M61



SH2_StructureTable.pdf(104KB)The structures of a large number of SH2 domains have been determined, often in complex with peptide or other ligands, and in some cases as part of larger multi-protein complexes. This table provides an overview of the current state of our structural understanding of SH2 domains, with the Protein Database (PDB) structure accession codes for the available structures indicated.